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Changing the Economics of Peptide Manufacturing.

Changing the Economics of Peptide Manufacturing.

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A pharmaceutical peptide manufacturer built on high-shear synthesis. Faster cycles, less material, lower cost.

What We Do

Amidera makes the active ingredients inside peptide medicines. We focus on the hardest peptides to manufacture, and on the economics of making them at scale.

Amidera makes the active ingredients inside peptide medicines. We focus on the hardest peptides to manufacture, and on the economics of making them at scale.

Amidera makes the active ingredients inside peptide medicines. We focus on the hardest peptides to manufacture, and on the economics of making them at scale.

Complex
peptides

The cyclic, glycosylated and phosphorylated sequences that are slowest and most costly to make today.

High-shear synthesis

Fast mixing and controlled heat complete each coupling in seconds, on far less reagent.

Scale-out manufacturing

Capacity grows by adding standard reactors in parallel, not by building bigger plants.

The Problem

Demand is outpacing the capacity to make it.
The key is the chemistry.

The reason is clear: Conventional synthesis forces every step with large excesses of reagent and solvent, then throws most of it away. The longer and more complex the peptide, the worse it compounds, and the harder capacity is to add.

[01]

[01]

Reagent
excess

Reagent excess

[02]

[02]

Long cycle
times

Long cycle times

[03]

[03]

Low
yields

Low yields

[04]

[04]

Heavy
purification

Heavy purification

The Solution

Amidera's platform forces each reaction to completion in seconds, on a fraction of the reagent. Faster couplings, cleaner chains, and far less waste at every step.

[01]

Mix hard: Fast stirring at 1,200 rpm drives each coupling to completion in seconds, not minutes.

[02]

Heat, controlled: Holding 90°C speeds the reaction without degrading the growing chain.

[03]

Use less: Each coupling finishes on as little as 2.0 equivalents of amino acid.

white truck on a road

The Evidence

Amidera's platform performs at levels demonstrated in published and peer-reviewed work.

Proven on the bench, not on paper.

A working reactor unit. A 29-residue glycopeptide synthesised in full. Results reproduced across triplicate runs, with resin integrity confirmed under the microscope.

Coupling time

10 sec

Conventional: minutes.

On-resin deacetylation

15 min

Conventional: hours.

Coupling time

10 sec

Conventional: minutes.

On-resin deacetylation

15 min

Conventional: hours.

Amino-acid excess

2.0 eq

Conventional: up to 5.0 eq.

Glycopeptide purity

80%

On 1.2 eq of building block.

Amino-acid excess

2.0 eq

Conventional: up to 5.0 eq.

Glycopeptide purity

80%

On 1.2 eq of building block.

The Model

Others scale one reactor up. We scale out.

Standard reactors running in parallel on shared feeds, under one control layer. Capacity grows by adding units, not by rebuilding the process.

[Demonstrated today]

[Demonstrated today]

A single working reactor unit.

[Designed for]

[Designed for]

Parallel arrays under unified control.

What we make

Built for complex peptides

[01]

Cyclic peptides

Head-to-tail and disulfide-bridged architectures

[01]

Cyclic peptides

Head-to-tail and disulfide-bridged architectures

[02]

Glycopeptides

Multiple glycosylation sites completed in a single run

[02]

Glycopeptides

Multiple glycosylation sites completed in a single run

[03]

Phosphopeptides

Densely phosphorylated, minimal to no chain damage

[03]

Phosphopeptides

Densely phosphorylated, minimal to no chain damage

[04]

Long modified sequences

Where conventional synthesis breaks down

[04]

Long modified sequences

Where conventional synthesis breaks down

[05]

Site-selective modification

Glyco and phospho without side reactions

[05]

Site-selective modification

Glyco and phospho without side reactions

[06]

Reproducible at bench scale

Confirmed across triplicate runs

[06]

Reproducible at bench scale

Confirmed across triplicate runs

What we make

Built for complex peptides

[01]

Cyclic peptides

Head-to-tail and disulfide-bridged architectures

[02]

Glycopeptides

Multiple glycosylation sites completed in a single run

[03]

Phosphopeptides

Densely phosphorylated, minimal to no chain damage

[04]

Long modified sequences

Where conventional synthesis breaks down

[05]

Site-selective modification

Glyco and phospho without side reactions

[06]

Reproducible at bench scale

Confirmed across triplicate runs

Heritage

A decade of chemistry, out of one of the world's leading peptide labs.

Amidera's high-shear platform began at the Hebrew University of Jerusalem, in the laboratory of Professor Mattan Hurevich, with Professor Chaim Gilon among its scientific minds. It is built on more than ten years of published, peer-reviewed research, licensed through Yissum, and protected by three patent families.

a high tech road

We make the ingredient today. We're building the platform around it.

Amidera is building a vertically integrated peptide platform. From advanced manufacturing through to a connected network of prescribers, compounding partners and specialty pharmacy, supported by an AI layer that matches capability to need across the chain.

The first layer is the Amidera Exchange: a verified network connecting prescribers with compounding pharmacies. No patient data, no prescriptions, no payments. Professionals connect, and everything clinical happens off the platform.

interface of the freight platform

Let's Get to Work

Better Peptide Economics Today. New Peptide Possibilities Tomorrow.

Better Peptide Economics Today. New Peptide Possibilities Tomorrow.